|
|
 |
|
|
Telephone 0191 518 1855
|
|
|
|
|
Milestone microwave synthesis systems
|
|
|
Microwave-enhanced
synthesis represents a fundamental step forward in the capabilities of synthetic chemistry. It allows organic chemists to work faster, generating higher yields with increased product purity, and to scale experiments
up reliably from milligrams to much larger quantities without the need to alter reaction parameters. It offers much more precise control over conditions of temperature and pressure than any previous technology.
Ultimately, by eliminating much of the time and effort from the process of performing chemical reactions, it allows chemists to focus on what is most important—the development of new compounds, or refined
methods for generating known products.
The Milestone advantage in organic synthesis resides in the ability to provide thorough and effortless scalability and uniquely offer tools to work with the entire range of
volumes in the synthetic process, from discovery, through parallel synthesis, to large-scale production
|
|
|
StartSYNTH
|
|
|
The StartSYNTH is an entry level system that has been specifically developed
for the academic laboratory environment, offering a full-featured microwave labstation at an affordable cost and with student-proof safety. The StartSYNTH makes available to academia the microwave technology
currently used in most advanced R&D organic chemistry industrial laboratories
|
|
|
|
|
|
Features
- Rapid results, microwave technology will permit classroom experiments to be completed faster, often in minutes
- No reactor, normal pressure glass reactor complete with 500 ml flask and reflux condenser
- Heavy duty microwave labstation engineered for the harsh laboratory environment
- Durable all-stainless steel construction for long life under heavy student usage
- Acid/organic solvent resistant cabinet coating
- Built-in magnetic stirrer for temperature homogeneity and increased yields
- IR temperature monitoring for accurate temperature control to ensure reproducibility
- Top opening for easy access to the cavity for introduction of standard glassware
- Green
Chemistry. microwave-enhanced chemistry uses a fraction of the solvents used with traditional methods
|
|
|
|
|
Teaching Lab Kit
16-position rotor allows reactions to be reproduced in up to 16 glass vessels. Several students can simultaneously carry out the same
reactions described in the QuickSTART Handbook or developed in the Research Lab Kit.
To ensure the maximum standards of safety, all reactions are carried out at normal pressure (reflux valve) or at
limited pressure 1.5 bar-20 psi (gravity valve). By fitting each vessel with a gravity valve, temperatures slightly higher than the boiling point of the solvent can be attained. The result is a further
reduction of the reaction time while at the same time ensuring safe operating conditions
|
|
|
Resources for students
|
|
|
|
|
|
|
|
|
QuickSTART Handbook. The Student's Guide
To save time for the itutor in preparing lpractical sessions or seminars, Milestone's Research Lab has already investigated and thoroughly tested several common organic synthesis reactions.
The Quick Start illustrated step-by-step procedures will enable students to carry out preset experiments with the NP reactor or the 16- position rotor
|
|
|
|
|
|
MicroSYNTH
|
|
|
The MicroSYNTH system, with its accompanying line of accessories, is the most innovative
labstation available for organic synthesis. As the system was designed with input from hundreds of users in a broad range of industries and academia, the MicroSYNTH platform therefore addresses the specific needs of
the organic chemist. The MicroSYNTH is the only system that offers homogeneous microwave heating throughout its entire multi-mode cavity. Users can process single or multiple samples simultaneously, and reactions
can be scaled-up to larger volumes in the same platform. Precise reaction monitoring and control, with an intuitive, easy-to-use software interface, provides exacting reproducibility and complete documentation
|
|
|
|
|
|
Features
- Dual magnetron
system with pyramid-shaped diffuser for homogeneous microwave distribution
- User-selectable continuous and pulsed microwave emission
- All stainless-steel construction with highest safety through unique pressure responsive-door
- Increased reproducibility through reliable magnetic stirring of solutions in all vessels
- Increased reproducibility through homogeneous heating preventing localised hot and cold spots
- Flexibility through use of any solvent even use non-polar microwave transparent solvents
- Advanced User Interface via compact terminal with bright, full-colour, touch-screen display
|
|
|
|
Applications
|
|
|
The Milestone advantage in microwave-enhanced organic synthesis resides in the ability to provide thorough and
effortless scalability. The systems offer tools to work with an entire range of volumes in the synthetic process, from discovery, through parallel synthesis, to large scale. The MicroSYNTH system and its accessories
are developed with safe scale-up in mind, thus offering the safest solution for a wide range of synthesis needs:
|
|
|
Large Batch Scale-up
The following accessories are available for large batch scale up reactions from normal pressure laboratory glassware to large volume pressure vessels
|
|
|
Accessory
|
HPR500
|
HPR1000
|
Normal pressure glassware
|
|
Vessel material
|
High-purity TFM
|
High-purity TFM
|
Borosilicate glass
|
|
Vessel volume
|
500 ml
|
1000 ml
|
Up to 4000 ml
|
|
Working volume
|
5 to 250 ml
|
100 to 500 ml
|
Up to 2000 ml
|
|
Maximum temperature
|
250°C
|
250°C
|
250°C
|
|
Maximum pressure
|
14 bar
|
8 bar
|
Normal pressure
|
|
|
|
Parallel Format Scale-up
The following accessories are available for scaling-up reactions using a parallel format in the Milestone MicroSYNTH. Refer to Rotors and Sensors for details
|
|
|
Accessory
|
Q20
|
SK-10
|
SK-6 LV
|
|
Vessel material
|
Quartz
|
High-purity TFM
|
High-purity TFM
|
|
Number of vessels
|
20
|
10
|
6
|
|
Vessel volume
|
45 ml
|
100 ml
|
270 ml
|
|
Working volume
|
3 to 30 ml
|
10 to 60 ml
|
50 to 160 ml
|
|
Maximum temperature
|
250°C
|
250°C
|
250°C
|
|
Maximum pressure
|
40 bar
|
100 bar
|
10 bar
|
|
|
|
RotoSYNTH
|
|
|
The RotoSYNTH is a unique product that allows for the homogeneous microwave heating of
the sample whilst physically rotating the reaction vessel. Vessels with different volumes are additionally available to fit user requirements. The rotation of the vessel mixes the solid reactants that assures
temperature homogeneity even with large sample amounts. A vacuum extraction system can be incorporated into the system for removal of gases produced or for synthesis under vacuum condition. Reactions can also be
performed with introduced gases. Single or multiple reactions can be carried out with full control and documentation of the synthesis process
|
|
|
Features
- A range of volume vessels available up to 4L enabling scale-up of reactions
- Optional vacuum extraction system for fast removal of evolved gases during reactions
- Synthesis under vacuum or with introduced gases
- Constant agitation of sample even with large volumes/weights
- Constant monitoring and control of temperature
- Control of rotation rate ensures optimal mixing
- Range of applications from dry media reactions, catalysis, and material coating
|
|
|
|
|
FlowSYNTH
|
|
|
|
|
|
Continuous Flow Scale-Up
The new FlowSYNTH system is a continuous flow microwave reactor that represents the link between laboratory-scale
reactions and industrial-scale production.
This revolutionary system allows chemists to scale-up reactions from grams to kilograms.
If the synthesis chemistry has already been optimised with
other Milestone microwave systems, the method can be easily transferred to the FlowSYNTH, that uses a flow-through reaction scheme with full control of all reaction parameters
|
|
|
|
Features
- Easy scale-up from grams to kilograms
- Purity of reaction products. Fast heating and cooling minimize reaction by-products
- Capability to fulfill large productivity needs. Flow rate adjustable from 12 to 100 ml/minute
- Advanced temperature and pressure control. Run reactions at temperatures up to 200°C, and pressures up to 30 bar
- Full compatibility with other Milestone microwave systems where reactions already optimised can be easily adapted to run in the FlowSYNTH
- Inherent safety -only relatively small quantities of reactants are moving through the continuous flow reactor, thus avoiding any risk associated with the handling of very
large volumes
|
|
